On the Nile's east bank sits Luxor, a onetime stronghold for Egyptian pharaohs. Key sites include Luxor Temple, Karnak Temple, and the Valley of the Kings.

A charming city nestled on the banks of the Rhine, Mainz, Germany lies southwest of Frankfurt and is replete with historic buildings and famous museums. The city's Altstadt district meets the river's edge and boasts a variety of beautiful and fascinating landmarks.

Wisconsin is bordered by two Great Lakes (Superior and Michigan). Milwaukee is the key city, and popular for the Harley-Davidson Museum, the Public Museum, and various beermakers' brewery tours.

More than 300 days of sunshine annually (more than San Diego or Miami Beach) earns Denver high marks with visitors and make sunglasses a must. For the city's most energetic shopping, dining and entertainment spots, point your compass in the direction of Larimer Square, the Tivoli, LoDo and the 16th Street Mall.

Belgium is located north of France and its residents are some of the most friendly in Europe. This country is the diamond capital of the world — visit its many museums, castles, cathedrals, fine art and food.